dl cardiac bioage model  (BioAge Labs)

Journal: Optometry and Vision Science

Article Title: Association of retinal image–based, deep learning cardiac BioAge with telomere length and cardiovascular biomarkers

doi: 10.1097/OPX.0000000000002158

Figure Lengend Snippet: Diagrammatic representation of how the deep learning model and aggregation models are integrated to produce an individual's cardiac BioAge. *CLAiR is the deep learning model that produces the baseline cardiovascular risk score and comprises a series of deep learning models that first identifies which eye is being assessed, before analyzing the retina for a variety of biomarkers as described. *K-NN = K-nearest neighbors method. BioAge = biological age.

Article Snippet: Multiple confounding risk factors and reverse causation mean that any observed associations between leukocyte telomere length and cardiovascular disease should be interpreted with caution; however, studies using Mendelian randomization provide compelling evidence for a relationship between leukocyte telomere length shortening and an increased risk of both atherosclerotic cardiovascular events and an increased risk of hypertension., , Irrespective of the mechanism by which leukocyte telomeres shorten, our findings indicate that, whether assessed by traditional biomarkers or leukocyte telomere length, our novel cardiac BioAge DL model could be used as a novel surrogate biomarker for cardiac health.

Techniques:

Journal: Optometry and Vision Science

Article Title: Association of retinal image–based, deep learning cardiac BioAge with telomere length and cardiovascular biomarkers

doi: 10.1097/OPX.0000000000002158

Figure Lengend Snippet: Chronological and cardiac BioAge, categorized by mean Z -adjusted log T/S LTL ratio deciles for males and females

Article Snippet: Multiple confounding risk factors and reverse causation mean that any observed associations between leukocyte telomere length and cardiovascular disease should be interpreted with caution; however, studies using Mendelian randomization provide compelling evidence for a relationship between leukocyte telomere length shortening and an increased risk of both atherosclerotic cardiovascular events and an increased risk of hypertension., , Irrespective of the mechanism by which leukocyte telomeres shorten, our findings indicate that, whether assessed by traditional biomarkers or leukocyte telomere length, our novel cardiac BioAge DL model could be used as a novel surrogate biomarker for cardiac health.

Techniques:

Journal: Optometry and Vision Science

Article Title: Association of retinal image–based, deep learning cardiac BioAge with telomere length and cardiovascular biomarkers

doi: 10.1097/OPX.0000000000002158

Figure Lengend Snippet: Mean biomarkers for individuals in the top quartile of cardiac BioAge (Q1) compared with the bottom quartile (Q4) across all telomere length deciles

Article Snippet: Multiple confounding risk factors and reverse causation mean that any observed associations between leukocyte telomere length and cardiovascular disease should be interpreted with caution; however, studies using Mendelian randomization provide compelling evidence for a relationship between leukocyte telomere length shortening and an increased risk of both atherosclerotic cardiovascular events and an increased risk of hypertension., , Irrespective of the mechanism by which leukocyte telomeres shorten, our findings indicate that, whether assessed by traditional biomarkers or leukocyte telomere length, our novel cardiac BioAge DL model could be used as a novel surrogate biomarker for cardiac health.

Techniques:

Journal: Optometry and Vision Science

Article Title: Association of retinal image–based, deep learning cardiac BioAge with telomere length and cardiovascular biomarkers

doi: 10.1097/OPX.0000000000002158

Figure Lengend Snippet: Distribution of the mean biomarkers for male and female individuals in the top quartile of cardiac BioAge top quartile (TopQ) compared with the bottom quartile (BotQ), categorized by Z -adjusted log T/S leukocyte telomere length decile. BioAge = biological age.

Article Snippet: Multiple confounding risk factors and reverse causation mean that any observed associations between leukocyte telomere length and cardiovascular disease should be interpreted with caution; however, studies using Mendelian randomization provide compelling evidence for a relationship between leukocyte telomere length shortening and an increased risk of both atherosclerotic cardiovascular events and an increased risk of hypertension., , Irrespective of the mechanism by which leukocyte telomeres shorten, our findings indicate that, whether assessed by traditional biomarkers or leukocyte telomere length, our novel cardiac BioAge DL model could be used as a novel surrogate biomarker for cardiac health.

Techniques: